MAPT and Alzheimer disease: Alzheimer’s (AD) and Parkinson’s (PD) diseases are the two most prevalent neurodegenerative disorders, and they are characterized by the aberrant accumulation of aggregates, Amyloid β (Aβ) in senile plaques and Tau in neurofibrillary tangles in AD, and α-synuclein in Lewis bodies in PD [7,8].