Inhibition of TGF-β enhanced the proinflammatory potential of TANs (N1), including cytotoxic CD8+ T lymphocyte activation, reactive oxygen species-dependent direct killing of tumor cells, and high expression of proinflammatory cytokines such as TNF-α and CCL3 and the costimulatory molecule ICAM-1. This evidence concerns the gene CD8A and neoplasm.