The first tumor-accelerated responses at 1 h after TPA treatment began with genes in “deregulated cellular metabolism”, with the up-regulation of CYP1a1 and CYP1b1 (Figure S10), and with genes in “tumor-promoting inflammation”, with the up-regulation of prostaglandin E synthase in prostanoid biosynthesis (Figure S34). Here, CYP1B1 is linked to neoplasm.