There are also evidences that collagens together with fibronectin, integrin, and laminin, and other components of ECM, are directly involved in tumor initiation and progression to metastasis by engaging in the EMT program by inducing signals through focal adhesion kinase, a core component of integrin signaling, promoting ERK and PI3K signaling pathways [30,31]. This evidence concerns the gene LAMB2 and neoplasm.