Results showed that high expression of BGN (p = 1.2 × 10−8), COL5A1 (p = 1.3 × 10−4), COL10A1 (p = 5.7 × 10−4), COL12A1 (p = 2 × 10−3), CTHRC1 (p = 1.1 × 10−4), SULF1 (p = 3.8 × 10−4), and THBS2 (1.2 × 10−6) are significantly correlated with poor overall survival and may be effective prognostic biomarkers for GC. The gene discussed is COL10A1; the disease is gastric cancer.