SIRT2 importance in colorectal cancer is also assessed by the evidence that a SNP (small nucleotide polymorphism) in 3′-UTR (untranslated) of SIRT2 sequence impeding hsa-miR-376a-5p binding to SIRT2 can increase patient susceptibility to colorectal cancer development [97]. The gene discussed is SIRT2; the disease is colorectal cancer.