In order to determine whether higher tumor infiltration by 3KO OT-1 CD8+ cells was correlated with the observed tumor growth retardation and increased survival, tumors were analyzed for OVA-peptide specific T cells (Vβ5, β-chain of the OVA-specific TCR) upon reaching a volume of 1500 mm3 or at day 16 after ATT. This evidence concerns the gene CD8A and neoplasm.