JAK2 and essential thrombocythemia: Moreover, in another study of ET patients, the authors investigated the relationship between ROS, chronic inflammation, total antioxidant capacity, leukocytosis, JAK2-V617F mutation, and disease progression to myelofibrosis, and concluded that chronic inflammation and oxidative stress are involved in the induction of ET disease and also in the transformation into secondary myelofibrosis or leukemia [81].