To identify potential regulators and target genes of aberrantly expressed IRX1, we compared LL-100 RNA-seq expression data from IRX1-positive (CMK, M07e, MKPL-1, and UT-7) with IRX3/IRX5-positive (MEGAL and OCI-AML3) AML cell lines. The gene discussed is IRX3; the disease is acute myeloid leukemia.