RUNX2 and acute myeloid leukemia: To analyze if this deregulating mechanism underlies the activation of IRX genes in AML, we inspected the published karyotypes of the corresponding cell lines (www.DSMZ.de, accessed on 15 February 2022) and shortlisted i(5)(p10) in OCI-AML3 and MKPL-1 and del(16)(q13q23) in MEGAL, which may have activating impacts.