A subsequent study showed that HOTTIP increased the expression of pluripotency markers octamer-binding transcription factor 4 (OCT4) and SRY-box transcription factor 2 (SOX2), and, in this way, it facilitated the stemness of breast cancer cells by regulating the miR-148a-3p/Wnt1 pathway [86]. The gene discussed is SOX2; the disease is breast cancer.