The main role of HOTAIR in breast cancer pathogenesis lies in the promotion of metastasis, and many pathways may lie behind this role, including those presented previously (Figure 1): TGFβ, Wnt/β-catenin, PI3K/Akt/MAPK, and vascular endothelial growth factor (VEGF) [98]. The gene discussed is VEGFA; the disease is breast cancer.