UBE2E3 and breast cancer: The mechanism of TOPORS-AF1 action in breast cancer is not fully understood, but according to the origin of this lncRNA from the topoisomerase I binding, arginine/serine-rich, E3 ubiquitin-protein ligase (TOPORS), it is considered to exert its tumor-suppressing action through regulation of breast cancer cell proliferation and apoptosis and regulation of p53/TP53 stability via ubiquitin-dependent degradation [102].