PTEN and cancer: Moreover, GATA3-AS1 was reported to interact with some oncogenes and tumor suppressor genes, such as zinc-finger protein 217 (ZNF217), phosphatase and tensin homolog (PTEN, TP53 tumor protein p53), and RB transcriptional corepressor (RB1), which predispose it to play an important role in the pathogenesis of many cancers [72].