Among RRMS patients with a significantly increased percentage of CD8+ Tregs with GITR expression, there was a significantly lower GITR MFI value among both CD4+ T cell populations (CD4+CD25+ and CD4+CD25+FoxP3+), compared to healthy controls (Figure 3, Table S1). This evidence concerns the gene TNFRSF18 and relapsing-remitting multiple sclerosis.