We characterized subsets of suppressive CD8+ T cells (CD8+CD122+Helios+, CD8+CD25+FoxP3+) that are altered in the common clinical forms of untreated relapsing–remitting MS (RRMS) patients, with active episodes of neurological deficit (relapses), and analyzed the associations between these subsets and demographic parameters. Here, FOXP3 is linked to relapsing-remitting multiple sclerosis.