Tumor progression is assisted by CD4+ T regulatory cells, type 2 CD4+ T cells, type 2 natural killer T cells, myeloid-derived suppressor cells, M2 or tumor-associated macrophages, B cells, and possibly mast cells, whereas tumor destruction is supported by CD8+ T lymphocytes, type 1 CD4+ T lymphocytes, natural killer, type 1 natural killer T cells, M1 macrophages, and immune killer dendritic cells [16]. The gene discussed is CD4; the disease is neoplasm.