The two most commonly studied SNP variants of the TERT gene are rs2736100 and rs2736098, which are related to the risk of both hematologic and solid cancers: rs2736100 was associated with an increased risk of thyroid, bladder, and lung cancer, glioma, and MPNs, whereas rs2736098 increased the risk of bladder and lung cancers. The gene discussed is TERT; the disease is lung cancer.