In several studies of GWAS, whole-exome sequencing (WES) or SNP arrays performed in MPN patients identified germline mutations or common genetic polymorphisms in multiple genes including MECOM, HBS1L-MYB, SH2B3 (LNK), TET2, ATM, CHEK2, LINC-PINT, ATG2B, GSKIP, RBBP6 and GFI1B, or epigenetic modifiers as ASXL1, DNMT3A, TET2, IDH2, and NF1 (Figure 1) [11,12,39,40,46]. The gene discussed is SH2B3; the disease is myeloproliferative neoplasm.