Histological and immuno-histochemical analyses of transverse spinal cord sections from ptch+/− and wt mice, sacrificed on day 20 after the MOG inoculation, revealed the pathogenic hallmarks of autoimmune neuro-inflammation in wt sections, while the sections from most ptch+/− animals were almost unaffected by EAE (Figure 7). The gene discussed is MOG; the disease is inflammation.