INS and obesity due to melanocortin 4 receptor deficiency: In addition, according to data reported in clinical trials, the continuous administration of fragmented Lactobacillus amylovorus CP1563 (heat inactivated, lyophilized and then milled) for 12 weeks significantly reduces whole body and visceral fat, ameliorates markers related to glycaemic control (reduced fasting blood glucose and insulin levels) and improves dyslipidemia (reducing blood TG, and total and LDL cholesterol levels) in subjects featuring class I obesity [80].