In a long term follow up study of 1320 patients with type 2 diabetes and an eGFR ≥ 30 mL.min−1 1.73 m−2, Tan et al. demonstrated that Gal-3 was independently associated with doubling of serum creatinine (HR 1.19 CI95%[1.14, 1.24], p < 0.001) even after adjusting for chronic renal risk factors, baseline eGFR, and albuminuria status [84]. The gene discussed is LGALS3; the disease is type 2 diabetes mellitus.