Later studies, in a big meta-analysis enrolling 5226 patients, Zhang et al. confirmed this association between Gal-3 and an increased risk of all-cause mortality and cardiovascular (CV) event in CKD patients (HR:1.379, [1.090, 1.744]) and associated with the risk of CV events in CKD patients (HR = 1.054, CI95%[1.007, 1.102])[97]. The gene discussed is LGALS3; the disease is chronic kidney disease.