MYC and neoplasm: c-MYC was identified as one of the genes that showed 2-fold downregulation in HCC97H cells treated with ExoHEK-CPE-shRNA versus ExoHEK-CTRL-shRNA, using a Human Tumor Metastasis −RT2 Profiler PCR Array (QIAGEN, Cat# 330231 PAHS-028ZA; data not shown), and hence, was chosen for further validation in this study.