PTEN and hepatocellular carcinoma: Recent reports have shown that exosomes released from malignant hepatocellular carcinoma (HCC) cells can increase the tumorigenic and migratory functions of low-metastatic HCC cells by inducing EMT (epithelial- mesenchymal transition), via the MAPK/ERK pathway [5], or by transferring miR-92a-3p to target PTEN and activating downstream Akt/Snail pathway [6].