Figure 2A–E shows that significantly higher CPE mRNA copy numbers are present in exosomes released from malignant cancer cells compared to those released from cancer cell lines with low malignancy, across various types of cancer, such as HCC, glioblastoma, prostate cancer, colon cancer, and pancreatic cancer. These data indicate that exosomes secreted by malignant cancer cells have elevated levels of CPE mRNA copy numbers compared to their low-malignant counterpart. This evidence concerns the gene CPE and hepatocellular carcinoma.