In general, the over-expression of Cyclin D1 is associated with tumor progression, chemotherapeutic resistance, and metastasis [44,45], while the upregulation of c-MYC, a transcription factor that regulates proliferation and cell-cycle progression, is strongly correlated with poor prognosis in liver cancer patients, including metastasis [46]. The gene discussed is CCND1; the disease is neoplasm.