⬇ Lipogenic markers genes (Fasn in non-tumor) ⬇ Fibrosis markers (Emr1, Itgax in non-tumor) ⬇ Cell senescence markers (Cxcl1 in tumor lesion; p21, Cxcl1, MMp12, mmp13 in non-tumor) ⬆ β-oxidation (PPAR-α in tumor lesion; PPAR-α, CPT1, PGC1 in non-tumor) ⬇ Cell apoptosis (Bax and Pcna). The gene discussed is MMP12; the disease is neoplasm.