TNF and fatty liver disease: Administration of canagliflozin to HFD-fed diabetic Wistar adult male rats resulted in reduced hepatic steatosis through amelioration of oxidative stress, inflammation and apoptosis, as indicated by reduced plasma malondialdehyde (MDA) levels, serum tumor necrosis factor (TNF) and caspase-3 levels, as well as hepatic expression of interleukin-6 (IL-6) [128,129].