In our cohort of type 3 VWD patients, the mutation detection rate was about 94%, following completing genetic diagnostic tests including multiplex ligation-dependent probe amplification (MLPA) as well as Sanger DNA sequencing of the promotor, coding regions, and conserved consensus splice site (ss) (exon/intron borders) of VWF [20,27]. The gene discussed is VWF; the disease is von Willebrand disease 3.