Furthermore, of interest, MMP1 (interstitial collagenase), with functions in inflammation and angiogenesis, is among the top 10 upregulated genes in both our currently and previously reported VWD patients, as well as the CRISPR/Cas9-engineered VWF-deficient ECFCs, indicating the significance of impaired VWF/WPBs on overall protein expression in endothelial cells (Schillemans et al., 2019). Here, VWF is linked to von Willebrand disease (hereditary or acquired).