Understanding the neuroprotective mechanism of the ACE2/Angiotensin-(1-7)/MasR axis in post-ischemic stroke and the modulation of this pathway by regulating the expression of the different specific biomarkers involved in both axes could open a new door for a potential therapeutic target to elicit neuroprotection i.e., improve neuro-gliogenesis and/or synaptogenesis for COVID-19-mediated ischemic stroke. This evidence concerns the gene AGT and ischemic stroke.