This is followed by the development of endothelial dysfunction and/or endotheliitis, which is primarily due to direct viral infection and the downregulation of ACE2 receptors and ACE2/angiotensin (1–7)/mitochondrial assembly receptor (MasR) (ACE2/Ang-(1-7)/MasR) axis [4]. This evidence concerns the gene MAS1L and viral infectious disease.