NLRP3 and ischemic stroke: Alarmingly, an increase in the activity of NLRP3 inflammasome has been associated with ischemic stroke because the activated NLRP3 inflammasome is thought to mediate neuro-glial cell aberration or dysfunction and cerebral edema, leading to neuro-glial cell death by producing various pro-inflammatory agents (i.e., cytokines) [66].