Hence, in this section, we describe and propose converging approaches targeting these molecular and cellular mechanisms, focusing on the mediating role of the ACE2/Ang-(1–7)/MasR axis and NLRP3 inflammasome to expand the understanding of COVID-19 related ischemic stroke rehabilitation (i.e., neuroplasticity and brain repair). The gene discussed is NLRP3; the disease is ischemic stroke.