Within the OPTIMISTIC dataset, we found four pathways which were significantly enriched (OX40 Signaling Pathway; T-cell Exhaustion Signaling Pathway; Role of NFAT in Regulation of the Immune Response Pathway; and Systemic Lupus Erythematosus (SLE) Pathway), while in the DMBDI dataset, these four pathways plus a number of additional pathways were significantly enriched, particularly those involving immune function (Figure 3). This evidence concerns the gene TNFRSF4 and systemic lupus erythematosus.