CNR1 and fatty liver disease: It is known that blockage of cannabinoid receptor type 1 may result in attenuation of hepatic oxidative stress, as well as the impairment of inflammatory response by inhibiting the production of pro-inflammatory cytokines [58,59] Furthermore, Irungbam et al. recently demonstrated in both in vitro (AML12 liver cell line) and in vivo studies on mice with a global CB1R receptor knockout that lower CB1R signaling reduced liver steatosis via downregulation of perilipin 2—the protein that is involved in the suppression of lipolysis and lipid accumulation [60].