It is noteworthy that in vivo studies conducted by Gamelin et al. revealed that obese Wistar rats after a 12-week running period showed an increased expression of TRPV1 and CB1R both in the hippocampus or subcutaneous adipose tissue, which suggests potentially enhanced signaling within this ion channel and may result in the favorable course of obesity and other metabolic conditions [10,108]. Here, CNR1 is linked to obesity due to melanocortin 4 receptor deficiency.