NFKBIA and Epstein-Barr virus infection: The pathway depends on the ZNAs produced during the early stages of EBV infection, with ZBP1 activating RIPK1 to promote ubiquitination of IκBα and release of p50 and p65 (encoded by NFKBIA, NFKB1and RELA, respectively) (Figure 1B and Figure 6C).