Within the ILC1 cluster, RGS1, STAT3 and TNFRSF18 showed the most significant induction in CRC tissue, whereas RGS1, FCGR2A and CXCL3 were highly upregulated in activated DCs, NUPR1, CXCL2 and ZFP36L2 in activated fibroblasts, RGS1, GPR183 and TNFAIP3 in highly activated T cells, XBP1, TNFAIP3 and CXCL2 in pericytes and CXCL1, CXCL2 and CEBPB in epithelial cells (Figure 5C). The gene discussed is XBP1; the disease is colorectal carcinoma.