Proteomics studies of various cancer cell types indicated several factors and pathways involved in cell adhesion and MCS formation, such as MAPK, and PAM, Wnt, VEGF, MAPK, and PAM signaling, and factors like among others NFκB, TGF-β, FAK/RhoA/Rock or β-catenin [63,66,96]. This evidence concerns the gene PTK2 and cancer.