MYBPC3 and familial dilated cardiomyopathy: Point mutations contribute to 25–50% of all DCM cases [196], and among these, mutations in the titin gene (TTN) are the most common with mutations in other sarcomere genes, including MYH7, MYBPC3, TNNT2, and TPM1 being less common and affect different residues than mutations that cause HCM.