In this context, the relationship between peripheral Th1 and Th2 cytokines, also evaluated in these subjects, supports the imbalance of Th1/Th2 cytokines with increased IL-4+CD4+ T cells and IL-4+CD8+ T cells and decreased proportions of IFN-γ+CD4+ T cells, IL-2+CD4+ T cells, IFN-γ+CD8+, and IL-2+CD8+ T cells observed in children with autism [41,73]. This evidence concerns the gene IL4 and autism.