The current study confirms and expands on our recently reported findings in Ewing sarcoma (a form of pediatric bone cancer) [33], namely, that several additional cancer types, derived from mouse (C6-glioma), rat (PC-12) and human (HeLa, PC-3, DU-145) origins, similarly express CBRs exhibiting atypical receptor binding and signaling properties relative to canonical CB1 and/or CB2 receptors. The gene discussed is CNR1; the disease is central nervous system cancer.