In a study by Hafiz Uddin et al. in A2780, CIS-resistant cell line expression of MDR1/P-gp, BCRP and MRP1 was regulated by ALDH1A1-NEK-2 axis, and silencing of ALDH1A1 expression resulted in downregulation of P-gp, MRP1, and BCRP expression and increased sensitivity to CIS [27]. The gene discussed is NEK2; the disease is in situ carcinoma.