In addition, the MR can serve as an entry receptor for Dengue virus and can also interact with HIV-1 virions that may facilitate trans-infection of CD4+ T lymphocytes [117] like other cell surface molecules, including dendritic cell-specific ICAM-grabbing non-integrin (DC-SIGN) [118] and the integrin α4β7 [119]. This evidence concerns the gene CD4 and infection.