Studies in animal models overexpressing PPARα reported the onset of glucose intolerance and insulin resistance along with 5′ adenosine monophosphate-activated protein kinase (AMPK) decreased activity, reduced glucose transporter GLUT4, and peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC1α) expression. The gene discussed is PPARGC1A; the disease is Insulin resistance.