In particular, tumor necrosis factor (TNF)-α and interleukin (IL) 1 and 6 were increased during cachexia, and administration of creatine or the Zhimu and Huangbai herb pair (ZBHP) was able to reduce muscle and adipose tissue wasting, suggesting that modulation of inflammatory signaling may be an interesting therapeutic target in cancer-related cachexia. This evidence concerns the gene TNF and Cachexia.