Changes in the levels of Parkinson’s disease (PD)-associated proteins, such as PTEN-induced putative kinase 1 (PINK1), parkin, peroxisome proliferator-activated receptor coactivator- 1 alpha (PGC-1α), nuclear respiratory factor 1 (NRF1), and aminoacyl tRNA synthetase complex interacting multifunctional protein 2 (MFP-2), were demonstrated, lending support to the pathological relevance of cell senescence. This evidence concerns the gene PPARGC1A and Parkinson disease.