In our set-up, the modulation of GADD45A expression could, therefore, interfere not only with proliferation and cell cycle perturbations [34,67] but also with deregulation of molecular mechanisms maintaining the balance among stemness, proliferation and differentiation within cancer cells [71,72,73], suggesting the involvement of the ROS-P53-GADD45A axis. This evidence concerns the gene TP53 and cancer.