Similarly, infection of porcine intestinal epithelial cells (IPEC-J2) with porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis virus (TGEV) altered expression of ZO-1 and occludin, 1 h post infection, which correlated with increased permeability across the epithelial cell layer [204]. The gene discussed is OCLN; the disease is infection.