Therefore, it is plausible to hypothesize that the herein observed early induction of HBD-1, HBD-2, and LL-37 by AMN could be the result, at least in part, of the paracrine stimulation with TNF-α from the CHD, whereas IL-1β may regulate the delayed wave of AMP, which deserves to be further investigated. The gene discussed is TNF; the disease is coronary artery disorder.