CD8A and infection: In addition to the bacterial targets, AMP can also bind to host targets, and regulate their immune response: (i) AMP reduce the host inflammatory reaction caused by endotoxins; (ii) favor mast cell degranulation and histamine release, enhancing splenocyte and lymphocyte production of Th1 and Th2 cytokines; (iii) AMP have been shown to increase the production of chemokines released from immune and epithelial cells, favoring the chemoattraction of monocytes, neutrophils, mast cells, naïve T cells, CD8 T cells, immature dendritic cells, and endothelial cells to fight against infection [60,61].