Although our understanding of the mechanism responsible for miR-183-5p expression is limited at this moment, target mRNA analysis exhibited that specific regions on the miR-183-5p promoter might contain highly conserved binding sites for transcription regulators associated with obesity, such as peroxisome proliferators-activated receptor gamma (PPARγ) and CCAAT enhancer-binding protein alpha (C/EBPα). The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.