-Increased level of inflammatory infiltration in foci.-Increased level of viral myocarditis and pericarditis.-Increased level of CD4+ T cells, mast cells, and degranulation of mast cells in heart tissue.-Increased expression of ERα, ERβ, IFNγ and IL-17A cardiac tissue.-Increased level of TLR4, Caspase-1, and IL-1β in cardiac tissue.-Presence of fibrosis was seen in pericardium, vessels, and myocardium. The gene discussed is ESR2; the disease is pericarditis.