-Increase of body weight and cardiac hypertrophy were seen.-Cardiac rupture and increased dilation of systolic and diastolic were observed.-Increase of dilation of left ventricle and cardiac contraction.-Increase of monocytes and myeloid cell infiltration in the heart.-Accumulation of CD4+ T cells and CD8+ in cardiac tissue.-Increased expression of metalloproteinase-1 protein, ARG1, IL-4, NOS2, and COX2 in heart. Here, IL4 is linked to cardiac hypertrophy.