ITPR3 and breast cancer: Indeed, the IP3R1 IH expression score was significantly higher in BC tissue than in non-tumor tissue (0.75 ± 0.14 (N = 40) vs. 0.39 ± 0.14 (N = 18), respectively; p = 0.05); the same was true for the IP3R3 IH expression score (1.48 ± 0.12 (N = 41) vs. 0.22 ± 0.08 (N = 17), respectively; p < 0.0001) (Figure 1B).