SEPHS2 and obesity due to melanocortin 4 receptor deficiency: Indeed, in a recent study of animal models, a combination of hyperglycemia, long-term insulin resistance and obesity was linked to reduced mRNA expression of thioredoxin reductase 3 (Txnrd3) along with selenoprotein Gpx3 and selenophosphate synthetase 2 (Sephs2) in adipose tissue [80].