According to UniRed analysis, more associations to known BrCa pathways were found for CFTR and less for CCDC181 and HIST2H3PS2. Indeed, previous studies have shown that the aberrant methylation of CTFR has been correlated to the prognosis and diagnosis of BrCa [59], as well as to bladder cancer [60], hepatocellular carcinoma [61] and lung cancer [62]. This evidence concerns the gene CCDC181 and urinary bladder cancer.