It was reported that mitochondrial dynamics are essential due to the discovery that the alteration of the fusion proteins mitofusin 1 and 2 (MFN1/2) in mice and flies or dysregulated proteolysis of the IMM fusion protein optic atrophy protein 1 (OPA1) resulted in dilated cardiomyopathy and heart failure [53]. Here, MFN1 is linked to heart failure.