A paired up-regulation of HLA-G and PD-L1 and/or PD-L2 was found also in pancreatic cancer [71], papillary thyroid cancer [72], oral osteosarcomas [73], oral precancerous lesions [74], intraoral mucoepidermoid carcinomas [75], and adenoid cystic carcinomas of salivary glands [76], thus supporting the concept that the close interaction of HLA-G with PD-1 takes place in different human tumors to drive a successful evasion from the control of the immune system. Here, HLA-G is linked to thyroid gland papillary carcinoma.