The role of HLA-G as IC and in the progression of NB is further supported by the following findings: first, sHLA-G from patients’ sera inhibited NB cell lysis mediated by NK cells and specific cytotoxic T lymphocytes; second, high serum levels of sHLA-G correlated with a worse prognosis of NB patients [46]. This evidence concerns the gene HLA-G and neuroblastoma.