Furthermore, functional assays have validated that modulating expression profile of miR-34a-5p/HIF1A, miR-34a-5p/IGFBP2, miR-34a-5p/PIK3CB, miR-99b-5p/MTOR, or miR-96-5p/MAPKAPK2 using miRNA mimics/antagomir subsequently inhibits cell proliferation and promotes docetaxel-induced cytotoxicity in PCa cells. The gene discussed is PIK3CB; the disease is posterior cortical atrophy.