The novel panel of reciprocal miRNA-mRNA pairings within mTOR signaling (miR-34a-5p/HIF1A, miR-34a-5p/IFGBP2, and miR-99b-5p/MTOR) and VEGF signaling (miR-34a-5p/PIK3CB, and miR-96-5p/MAPKAPK2) have been suggested as critical miRNA-mRNA regulatory components in AA PCa (or more aggressive type of PCa). This evidence concerns the gene MAPKAPK2 and posterior cortical atrophy.