A novel panel of reciprocal miRNA-mRNA pairings (miR-34a-5p/HIF1A, miR-34a-5p/IGFBP2, miR-34a-5p/PIK3CB, miR-99b-5p/MTOR, and miR-96-5p/MAPKAPK2) were identified as core regulators contributing to the upregulation of mTOR and VEGF signaling in AA PCa. This evidence concerns the gene PIK3CB and posterior cortical atrophy.