IGFBP2 and posterior cortical atrophy: Since miRNA targeting causes either mRNA degradation or translational repression, we further investigated the protein levels of mTOR, PI3Kβ, HIF1α, IGFBP2 and MAPKAPK2 in PCa cells transfected with NS, miR-34a-5p mimic, miR-99b-5p mimic, or miR-96-5p antagomir.