Another study also indicated that miR-34a-5p directly targets HIF1A and inhibits its transcription, preventing PPP1R11/STAT3-induced EMT and metastasis in colorectal cancer (CRC) [42].To our knowledge, our study is the first report to confirm that transcription and translation of HIF1A is also negatively regulated by miR-34a-5p in PCa (Figure 5 and Figure 6). Here, STAT3 is linked to colorectal carcinoma.