Immunoblot analysis again confirmed that mTOR, PI3Kβ, HIF1α, and IGFBP2 were significantly upregulated, while MAPKAPK2 was downregulated in AA PCa (especially in MDA PCa 2b) in comparison with EA PCa cell lines (Figure 4A,B). The gene discussed is MAPKAPK2; the disease is posterior cortical atrophy.