As anticipated, transfection of miR-34a-5p mimic and miR-99b-5p mimic resulted in decreased PIK3CB, HIF1A, IGFBP2 and MTOR expression in AA and EA PCa cells when compared to PCa cells transfected with nonsense/scrambled (NS) miRNA control (Figure 5). The gene discussed is HIF1A; the disease is posterior cortical atrophy.