Unfortunately, we were not able to examine the in vivo anti-myeloma effect of the combination of BI-D1870 and ipatasertib, due to the uncertain in vivo performance of BI-D1870, and also due to the lack of a promising in vivo bioavailable inhibitor specific for RSK2-NTKD. The gene discussed is RPS6KA3; the disease is plasma cell myeloma.