TGM2 and cranioectodermal dysplasia: DH is often considered to develop as a result of prolonged gluten exposure and untreated CeD, but it is not known whether the autoimmune responses against TG2 and TG3 develop in certain patients in parallel, or whether TG3 merely becomes targeted via gradual loss of antigen specificity against TG2 in a subset of CeD patients.