We conducted a comparative study of the performance of two validated methods set up at the Laboratory of Clinical and Experimental Pathology (LCEP) (Nice, France), the BRAF VE1 IHC (accredited according to the ISO 15189 norm: www.cofrac.fr, accessed on 19 February 2022) and the BRAF Idylla Mutation test, on 90 melanoma FFPE samples, including 32 positive sentinel lymph nodes (SLN). The gene discussed is BRAF; the disease is melanoma.