Another study focused on TP53 and ASXL1 prognosis in AML and MDS reported that they are two independents factors associated with poor prognosis and short survival; nevertheless, none of the studies had reported the pathogenic significance of the particularly identified mutations on these genes, their importance on disease pathogenicity cannot be ignored and further functional validation should be done [58]. This evidence concerns the gene ASXL1 and myelodysplastic syndrome.