The diagnostic performance of PG and HE-4 increased in the case of moderate to severe atrophy as compared with any atrophy: Se and Sp for PGI/PGII ratio (cut off <3.03) were of 57.4% and 92.6%, for PGI/PGII ratio, respectively, and for HE4 (cut off >63.2 μg/mL) of 70.4% and 55.4%, respectively (Table 2). This evidence concerns the gene WFDC2 and Atrophy.