WFDC2 and Atrophy: Among other markers, the best diagnostic performance was observed with HE4, in particular in combination with PGI/PGII: Se of 69.7% and Sp 67.6% with AUC of 0.687 for any atrophy and Se of 85.2% and Sp of 52.0% with AUC 0.686 for moderate to severe atrophy (Table 2, Figure 1).