Although we first identified GLUT3 as a significantly upregulated DEG in hypoxic immortalized prostate epithelial cells, we showed that GLUT3 was also upregulated in response to hypoxia in other cell lines and models including transformed PrEC-Hahn cells, brain metastatic tumor-derived DU145 cells, xenograft tumors formed from these cell lines, and two different prostate cancer PDX specimens (isolated from a primary tumor and a bone metastatic tumor). Here, SLC2A3 is linked to Familial prostate cancer.