Such genes include those involved in survival, self-renewal (e.g., hTERT, ABC-Ts, Notch), and promoting the EMT (Epithelial-mesenchymal transition) phenotype (e.g., TAZ, Snail, Twist, Slug, Zeb-1/2); and (5) HIF-1α plays a central role in the hypoxia-activated reprogramming of the energy metabolism in cancer cells. The gene discussed is HIF1A; the disease is cancer.