In such a situation, a large amount of cytokines and chemokines are secreted, for example TNF-α, IL-1, IL-6, IL-8, which stimulate other cells of the immune system and the formation of a large inflammation focus, and, as a result, micro- and macro-vascular thrombosis leading to organ failure [14]. This evidence concerns the gene CXCL8 and deep vein thrombosis.