Based on its significantly higher IHC expression in peritubular capillaries and interstitial space of patients with CKD compared to controls, its stepwise abundance along with progression of interstitial fibrosis, which was also confirmed on the paired biopsy samples of the 15 transplanted kidneys, ADAMTS-4 might be a novel marker of CKD. The gene discussed is ADAMTS4; the disease is chronic kidney disease.